Towards a new approach of photoprotection

The sun is back, with its benefits but also its harmful effects. It is important to know that UV exposure (UVA and UVB) occurs all year round and leads to photoaging when the skin is left unprotected. Gattefossé has studied the effects of UVA radiation on epidermal stem cells.

Towards a new approach of photoprotection

The sun is a vital source of energy. The human knows how to make good use of it.

Sunlight plays a key role in the synthesis of essential biomolecules such as melatonin, vitamin D or endorphins.

But excessive sun exposure also leads to detrimental effects. On the skin, new data show a dramatic impact of UVA on epidermal stem cells.

80% of extrinsic aging is photoaging

A physical barrier between the inside and the outside, the skin is one of the most responsive organs to external aggressions, particularly to UV (Ultraviolet) radiation. Amongst all environmental factors responsible for extrinsic aging, repeated sun exposure is the most significant and photoaging is the major consequence. Photoaged skins feature a set of typical modifications: wrinkles and fine lines, altered microrelief, lack of luminosity and pigmentary disorders.

About sun rays

For decades, UVB rays have been considered more genotoxic than UVA. They are known to severely damage epidermis, causing local inflammation and sunburns and to penetrate to the heart of cells, down to the DNA. Their role in the generation of photoproducts and direct DNA lesions is clearly established.

Due to its capacity to penetrate deeper layers of the skin, UVA was mainly related to structural alterations of the dermis. But today, lots of scientific publications evidenced that UVA radiation is not as innocuous as previously thought.

There are several reasons to report:

  • UVA is abundant at the Earth surface: more than 20 times abundant in sun radiation than UVB.
  • It penetrates further into the skin, passing the epidermis and reaching the dermis, with damage described on both layers.
  • It dramatically increases the oxidative stress level in the skin and generates oxidative DNA lesions.
  • Endogenous DNA repair systems are overwhelmed by overexposure to UVA.

More precisely, research show that UVA is very likely to induce DNA lesions in the epidermal basal layer, which hosts the keratinocytes stem cells.

A survival pool for the skin to be protected

The epidermis is a living epithelium renewing every 3 weeks on average. Its renewal is constant during its lifetime. But only a specific population of keratinocytes can proliferate and initiate the cell renewal process: they are named keratinocyte stem cells and can be considered as the “mother” cells of the epidermis.

The integrity of these epidermal stem cells and their protection against environmental aggressors are absolutely key to ensure the long-term function and health of the epidermis.

In-depth research program

Together with a research group specialized in genotoxic stress, Gattefossé uncovered that although keratinocyte stem cells benefit from very efficient DNA protection and repair systems, they can still be affected by UVA. Indeed, DNA lesions induced by UVA in keratinocytes are associated to a weakening of their self-renewal capacity, their so-called “stemness” potential, ultimately related to functional and structural alterations of the epidermis.

Out of this work, Solastemis™, a plant-based active ingredient, has been developed with the objective to preserve keratinocytes stem cells from UVA-induced damage. Gattefossé’s R&D Director, Boris Vogelgesang, explains the main properties of this ingredient in a video:

Learn more about Solastemis™ by visiting Gattefossé’s website: